Prognostic impact of GPR56 in patients with colorectal cancer

G protein-coupled receptor 56 (GPR56) belongs to the adhesion subfamily, which plays a role in cell progression and survival. The aim of this study was investigate GPR56 gene line impact its protein expression on prognosis colorectal cancer (CRC) patients. effect tumor proliferation (WST-1 assay), invasion (Transwell migration assay, wound healing colony-forming ability (semisolid agar assay) explored. levels tissue samples 109 CRC patients were evaluated by immunohistochemistry. prognostic value GRP56 analyzed using univariate multivariate analyses. downregulation reduced as compared with that control sample (48 h; p = 0.042, 72 0.001). Downregulation abilities inhibited (p < 0.005). 5-year overall survival rate worse high-expression group low-expression (51.6% vs. 74.4%, 0.008). High significant factor for 0.001) level an important CRC, it may serve indicator